SB 431542 is an inhibitor of the transforming growth factor-beta 1 (TGF-β1) activin receptor-like kinases (ALKs). It is a selective and potent inhibitor of ALK-4, -5 (IC50 = 94 nM) and -7. SB431542 inhibits endogenous activin and TGF-β signaling without affecting more divergent BMP signaling utilizing ALK-1, -2, -3, and -6 (1,2). It has no effect on the other, more divergent ALK family members that recognize bone morphogenetic proteins (BMPs) such as ALK2, ALK3 or ALK6. It has also no effect on components of the ERK, JNK, or p38 MAP kinase pathways or on components of the signaling. SB 431542 at 1μM stimulates proliferation, differentiation, and sheet formation of endothelial cells derived from embryonic stem cells (3).
BioPioneer Inc专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
暂无问答
本网站将在规定时间内给予删除等相关处理。
