Product Description RecombinantHEK293celllineexpressinghumanPDE7A(phosphodiesterase7A, accession number NM_002603).Format Each vial contains 1 X 10⁶ cells in 1 ml of 10% DMSO.Introduction Phosphodiesterases(PDEs)regulatetheintracellularlevelsofcAMPandcGMPby hydrolyzingcAMPandcGMPtotheirinactive5’monophosphates.Thesecyclic nucleotidesplayanimportantroleassecondmessengersindiversephysiological functions. PDE7is a cAMP-specific enzyme andtwo PDE genes(PDE7A and PDE7B) havebeenidentified.PDE7Ais widelyexpressedinvarioustissuesincludingskeletal muscle, T lymphocytes, brain and pancreas. Inhibition of PDE7 activity by its inhibitors leads to elevated intracellular level of cAMP.

References Malik, R. et al.(2008) Cloning, stable expression of human phosphodiesterase 7A and developmentofanassayforscreeningofPDE7selectiveinhibitors.Appl. Microbiol. Biotechnol.77 (5): 1167-1173FanChung,K.(2006)Phosphodiesteraseinhibitorsinairwaysdisease.Eur.J. Pharmacol. 533(1-3):110-117