Description: Human secreted Programmed Cell Death 1 Ligand 1 (PD-L1)-Fc fusion protein, also known as CD274 and B7 homolog 1 (B7- H1), GenBank Accession No. NM_014143, amino acids 19-239, with C-terminalAvi-tag™ expressed in a HEK293 cell expression system and enzymatically biotin -labeled using Avi-tag™ technology. MW = 54 kDa.

Synonyms: PDL1, B7H1,PDCD1LG1, PDCD1L1, PDCD1 Ligand 1

Assay Conditions: PD-1-PD-L1 binding activity, measured using the using the PD-1:PDL1 [Biotinylated] Inhibitor Screening Assay Kit, BPS Bioscience, Catalog #72003.

Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Formulated in: 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol

Stability: >6 months at –70°C. Avoid freeze/thaw cycles.

References: 1. Freeman, G.J., et al., J Exp Med. 2000 Oct 2;192(7):1027-34. 2. Dong, H., et al., Nat Med. 1999 Dec;5(12):1365-9.